Growing understandings of the microbiome open possibilities to look at classic anthropological issues with fresh eyes. In ethnography from the Wari’ of western Brazil, bringing the animacy of place-based multispecies assemblages into focus expands interpretations of Wari’ praxis around biosocial identity, alterity and hospitality, death rituals, and landscape relations. Reflecting on what we may have been missing by discounting the empiricism of Indigenous “practical reason” in favor of immaterial, cognitively-focused interpretations foregrounds the double standard in anthropological respect for Indigenous knowledge and commitments to take Indigenous ontologies seriously. Thinking microbially enables us to ask new questions about the interplay between cultural forms and lived experience.